Associate Scientist II, Protein Sciences

Overview

We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein purification, bio conjugation and analytical techniques, who are comfortable working in a fast-paced entrepreneurial environment. The successful candidate will be part of cross-functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities

This lab-based position is onsite and will be located in Cambridge, MA.

Key Responsibilities

• Work closely with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales.

• Design, plan, and perform protein conjugation experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members.

• Support the purification, buffer exchange, characterization, and QC of protein and oligonucleotide conjugates by utilizing UV–Vis spectroscopy and HPLC

• Contribute to the maintenance of laboratory infrastructure and equipments.

• Support group organization, productivity, and expertise through collaboration and idea exchange.

• Assist in optimizing inventory system for proteins and protein conjugates.

• Meet quality, quantity, and timeline expectations for all assigned projects.

• Support discovery efforts in protein sciences.

• Maintain accurate and complete electronic notebook records.

• Communicate experimental plans and data to multiple cross-functional scientific teams.

Qualifications

• BS/MS degree in chemistry, chemical engineering, biochemistry, or a related field with 0–1 years of relevant laboratory experience in a biopharma or academic setting.

• Experience with modern bioconjugation chemistry and analytical techniques.

• Experience with instrumentation such as Agilent and ÄKTA HPLC systems, TFF, and UV–Vis spectrometry.

• Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, RP-HPLC, HIC, IEX, SDS-PAGE, UV–Vis spectroscopy)

• Experience developing new chromatographic methods is a plus.

• Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems.