Director/Senior Director, Development Program Management, CMC
- Compensation
- $224K–$296.8K / yr
- Location
- Boston
- Work setup
- Hybrid
- Seniority
- Senior
- Employment
- Not specified
- Experience
- 12+ years
- Category
- Not specified
- Posted
Skills
Must have
- Bachelor’s degree in a scientific, technical, or related discipline required; advanced degree preferred.
- Typically requires 10+ years of relevant biotechnology or pharmaceutical industry experience for Director level, or 12+ years for Senior Director level, including significant experience in CMC, pharma
- Small molecule drug substance and drug product development required; experience with API development and solid oral dosage forms strongly preferred.
- Demonstrated experience managing cross-functional CMC deliverables, timelines, risks, and documentation in support of early-stage regulatory submissions, including regulatory applications; exposure to
- Proven ability to influence without authority, drive alignment across technical and non-technical stakeholders, and ensure execution discipline across complex, matrixed Product Development Teams.
- Experience developing and maintaining CMC-specific project plans, dashboards, milestone charts, action logs, risk logs, and related project management tools.
- Strong analytical, facilitation, problem-solving, written communication, and verbal communication skills, with the ability to communicate effectively with both technical and non-technical stakeholders
- Proficiency with Smartsheet, Microsoft Project, Microsoft Office, and related project management tools required.
- PMP certification or equivalent project management training preferred.
Full description
Who We Are:
Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.
What We Do:
We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we submitted a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.
About the Role:
We are seeking a Director/Senior Director, Development Program Management, CMC to join our team. The Director/Senior Director, Development Program Management, CMC will provide strategic and operational project management leadership for CMC teams, with an initial focus on phase 1 and 2 compounds. This role will drive integrated planning, execution support, governance, and communication across multiple cross-functional programs and initiatives.
The successful candidate will partner closely with CMC and program stakeholders to translate strategy into clear, actionable execution plans; maintain high-quality project plans, dashboards, milestone trackers, risk and action logs; and ensure timely follow-up on key deliverables, decisions, dependencies, and risks. The role will also help strengthen project management practices through scalable tools, clear meeting governance, financial tracking, continuous improvement, and appropriate use of emerging technologies.