Schedule: Three 12-hour shifts (3/12s), Friday–Sunday
Employment Type: Full-time, exempt
Compensation: $130,000–$155,000 per year, depending on experience
Focus: Phase 1 clinical research, liver disease, gastroenterology, and hepatology
Reports To: VP of Research
Benefits: 4 weeks PTO, CME budget and time off, medical/dental/vision coverage, 401(k) with 6% company match, paid holidays, sick time, and disability coverage
Location & Logistics
Work Environment: On-site Phase 1 clinical research and specialty patient care setting
Schedule: Friday–Sunday, three 12-hour shifts per week
Weekly Structure: Three scheduled workdays with Monday–Thursday off
Travel: Interoffice travel may be required; company vehicle or mileage reimbursement options available
On-Call: Participation in the APP call rotation as applicable
About the Opportunity / A Day in the Life
We are seeking an experienced Nurse Practitioner (NP) or Physician Assistant (PA) to join a Phase 1 clinical research team in Chandler, Arizona. This is a specialized opportunity for an APP who understands clinical research and wants direct involvement in the evaluation of emerging therapies while providing high-quality care to patients with liver and gastrointestinal conditions.
Working three 12-hour shifts from Friday through Sunday, you will evaluate and manage standard-of-care and clinical research patients, conduct consultations and pretreatment reviews, perform medical and safety assessments, and support patients throughout their participation in clinical trials.
You will work in a Sub-Investigator capacity, collaborating closely with physicians, clinical research coordinators, recruiters, and other research professionals. Your responsibilities will include understanding assigned protocols, completing research visits, reviewing source documentation and informed consent records, and ensuring clinical decisions align with patient safety and study requirements.
This is a hands-on role with meaningful patient and study ownership. You will help manage patients from their initial evaluation through study completion and closeout while contributing to Phase 1 research and innovative treatment options.
Why This Role Stands Out
Three-day workweek: Friday–Sunday, 3/12s
Monday through Thursday off
Direct involvement in Phase 1 clinical trials and emerging therapies
Opportunity to serve as a Sub-Investigator and take meaningful ownership of research patients
Specialized exposure to GI, hepatology, and liver disease
Combination of autonomous clinical practice, research, and multidisciplinary collaboration
What We’re Looking For
NP or PA with previous clinical research experience
Strong understanding of research protocols and clinical trial processes
Knowledge of the responsibilities associated with serving as a Sub-Investigator
Ability to independently manage clinically complex patients
Strong attention to research documentation, patient safety, and protocol compliance
Collaborative professional who can effectively work across clinical and research teams
Job Duties & Responsibilities
Perform patient evaluations, consultations, and pretreatment reviews for standard-of-care and clinical research patients.
Serve in a Sub-Investigator capacity and support the clinical execution of Phase 1 research protocols.
Oversee appropriate aspects of clinical trial patient care and perform medical and safety reviews.
Diagnose conditions and make appropriate treatment decisions within established scope of practice.
Educate patients regarding therapeutic options available through applicable liver clinical trials.
Counsel patients and families and collaborate with physicians regarding appropriate direct-care interventions.
Serve as a primary clinical point of contact and assume responsibility for managing assigned patients.
Collaborate with clinical research coordinators, recruiters, physicians, and other research personnel to complete study visits.
Review source documentation, clinical charting, informed consent records, and study documentation for accuracy and completeness.
Maintain a thorough understanding of assigned protocols and communicate study requirements to the research team.
Perform applicable in-clinic procedures, including FibroScan, when appropriately trained and qualified.
Support assigned patients and studies from initial evaluation through study completion and closeout.
Required Qualifications
Graduate of an accredited Nurse Practitioner or Physician Assistant program
Current applicable NP or PA certification
Active or eligible license to practice in Arizona
Nurse Practitioner candidates must maintain current applicable RN and NP licensure and certification
Physician Assistant candidates must maintain applicable NCCPA certification
Previous clinical research experience with a strong understanding of research processes and protocols
At least 1 year of experience practicing as an NP or PA in a clinic or hospital setting
Ability to diagnose and manage clinically complex patients with minimal assistance
Strong verbal, written, and interpersonal communication skills
Ability to complete GCP and IATA training upon hire
Ability to maintain all certifications required by the applicable department or division
Valid documentation and authorization to work in the United States
Leadership or mentoring experience within clinical research
Commitment to continued professional development and additional certifications
Knowledge & Skills
Strong understanding of clinical research processes, protocols, and patient safety requirements
Ability to provide patient care with minimal supervision
Strong clinical judgment and independent decision-making ability
Ability to recognize and proactively address patient concerns
Ability to make appropriate referrals based on clinical findings
Understanding of quality-of-care metrics and established clinical standards
Strong systems and process problem-solving skills
Ability to mentor research personnel on standard operating procedures and best practices
Resourceful approach to problem-solving and utilizing available clinical resources
Proficiency with Microsoft Outlook, Word, Excel, PowerPoint, and OneDrive
Experience with or ability to effectively use electronic medical record systems, including eCW
This Role Is Likely a Fit If You…
Want a three-day workweek with Monday–Thursday off.
Have clinical research experience and understand protocol-driven patient care.
Want direct involvement in Phase 1 clinical trials and emerging therapies.
Enjoy combining advanced clinical practice with research responsibilities.
Are comfortable managing complex patients with a high degree of autonomy.
Thrive in a collaborative environment with physicians and clinical research professionals.
This Role May Not Be a Fit If You…
Are unavailable to consistently work Friday, Saturday, and Sunday.
Do not have previous clinical research experience.
Prefer a traditional outpatient position without research or protocol responsibilities.
Are uncomfortable with detailed source documentation and regulatory requirements.
Prefer a role with minimal responsibility for complex patient management.
Are looking for a fully remote or hybrid position.
Benefits & Perks
Medical, dental, and vision insurance
HSA plan options with employer contribution
4 weeks of PTO
5 days of sick time
7 company holidays plus 2 half-days
Continuing Medical Education (CME) budget
Necessary CME time off
401(k) with 6% company match
Short- and long-term disability coverage
Shared company vehicles for required business travel
Why Join Us
This position offers an uncommon combination of Phase 1 clinical research, specialty medicine, patient ownership, and a three-day workweek. You will have direct involvement in clinical trials, contribute to patient safety and study execution, and collaborate with an experienced multidisciplinary research team.
The Friday–Sunday 3/12 schedule provides four consecutive days off each week, while the clinical scope offers the opportunity to deepen your expertise in research, gastroenterology, hepatology, and liver disease.
If you are an experienced NP or PA with clinical research experience who is looking for a specialized role and a distinctive three-day schedule, we encourage you to apply.
Requirements
Graduate of an accredited Nurse Practitioner or Physician Assistant program
Current applicable NP or PA certification
Active or eligible license to practice in Arizona
Nurse Practitioner candidates must maintain current applicable RN and NP licensure and certification
Physician Assistant candidates must maintain applicable NCCPA certification
Previous clinical research experience with a strong understanding of research processes and protocols
At least 1 year of experience practicing as an NP or PA in a clinic or hospital setting