Senior Manager/Associate Director Clinical Operations

Lycia Therapeutics (Nasdaq: LYCA) is a clinical-stage biotechnology company using its proprietary lysosomal targeting chimera (LYTAC) platform to discover and develop therapeutics that degrade extracellular and membrane-bound proteins. These proteins drive a wide range of difficult-to-treat diseases, including autoimmune, inflammatory, and allergic conditions. Lycia was established in 2019 in collaboration with academic founder and Nobel Laureate Carolyn Bertozzi, Ph.D., professor of chemistry and HHMI investigator at Stanford University. In October 2026, Lycia completed an initial public offering, and its common stock now trades on the Nasdaq Global Select Market under the ticker symbol “LYCA.” Lycia is headquartered in South San Francisco.

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Position Summary

The Senior Manager/Director Clinical Operations will be responsible for oversight and management of up to 2 early phase clinical programs in collaboration with the selected Clinical Research Organization (CRO).

Primary Responsibilities:

• Create and execute clinical operational strategic plans in line with product strategy and resource allocation.

• Develop study feasibility, cost estimates, input into contracts, work/change orders and analyze tools and processes to support outsourcing efforts.

• Track clinical program study finances and monthly accruals and review/approve associated clinical site and vendor invoices.

• Build, develop and train internal staff and external vendors, structure department for enhancing efficiency, and create a highly engaged work environment for attracting and retaining highly qualified clinical operations professionals.

• Develop and ensure compliance with SOPs and guidelines, FDA regulations and current ICH GCP guidelines.

• Oversee and maintain the relationships with Contract Research Organizations, vendors, and investigative sites.

• Participate on clinical operations and study team meetings.

• Maintain a high level of professional expertise through familiarity of clinical literature, knowledge of therapeutic area, current medical practice and pharmaceutical regulations.

Additional Expectations

• Although a remote position, it may be necessary to travel to corporate headquarters up to 2 times per year.

• Ability to travel to clinical sites or to the CRO, as necessary to support trial management.

Qualifications:

• B.A/B.S required; M.S., PhD, PharmD, MD or other related advanced scientific degree strongly preferred.

• Minimum of 7 years for manager and 12 years for director level with progressive advancement within clinical operations in the pharmaceutical/biotech industry.