Bachelor’s degree in life sciences, biomedical sciences, chemistry, engineering, or related field
8+ years of relevant experience in biotech, biopharma, or related life sciences industry
5+ years of project or program management experience supporting drug discovery and/or development programs
Demonstrated experience managing biologics programs in oncology or closely related therapeutic areas
Strong understanding of drug development from discovery through IND, including: discovery research and candidate selection IND-enabling toxicology and pharmacology CMC and analytical development for b
Proven ability to lead highly matrixed, cross-functional teams without direct authority
Excellent communication, facilitation, organizational, and stakeholder management skills
Strong problem-solving abilities with demonstrated experience managing complex timelines, dependencies, and risks
Experience preparing executive-level presentations, status reports, and governance materials
Nice to have
Advanced degree (MS, PhD, PharmD, or MBA) in a relevant scientific or business discipline
Experience with monoclonal antibodies, bispecifics, ADCs, or other complex biologic modalities in oncology
Mandarin-English Bilingual Ability
PMP or related project management certification is a plus and biotherapeutics life cycles
Experience in a fast-paced, innovation-driven biotech environment
Full description
SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.
We are seeking a Senior Project Manager, R&D to support cross-functional planning and execution for oncology biologics programs from early discovery through IND-enabling activities and support of IND submission. This role will partner closely with Research, Translational Sciences, Nonclinical, Regulatory, Clinical Pharmacology, and external partners to drive integrated development strategy, stage-appropriate planning, risk management, and operational execution.
The ideal candidate brings strong biotech or biopharma drug development experience, excellent cross-functional leadership skills, and a deep understanding of the milestones, dependencies, and decision points required to advance innovative biologics programs into the clinic. This individual will serve as a strategic and operational hub for assigned programs, ensuring alignment, accountability, and timely progress across the portfolio. A key aspect of this role is the effective use of meeting management to strengthen stakeholder integration, communication, decision-making, and execution across internal and external teams.
This position is full-time onsite in Bothell, WA.
Key Responsibilities
Lead cross-functional project planning and execution for oncology biologics programs spanning target/lead discovery, candidate selection, IND-enabling studies, CMC development, and IND submission
Build, maintain, and drive integrated project plans, timelines, milestones, scenarios, and critical path analyses across multiple functional areas
Partner with program leaders and functional heads to define development strategy, key objectives, deliverables, governance milestones, and resource assumptions
Facilitate cross-functional team meetings, sub-team meetings, and governance reviews; document decisions, action items, risks, and next steps
Identify interdependencies, operational risks, and potential bottlenecks early; drive mitigation plans and escalate issues appropriately
Ensure alignment across Research, Nonclinical, CMC, Regulatory, Clinical, Biomarker/Translational, Quality, and partner organizations
Drive program team preparedness for major stage gates, including candidate nomination, development candidate selection, IND-enabling study initiation, and IND submission
Support budget planning, resource tracking, and external partner/CRO coordination as needed
Develop concise and decision-oriented communications for senior leadership, governance bodies, and key stakeholders
Track progress against program goals and proactively highlight deviations, tradeoffs, and decision needs
Promote disciplined program management practices, clear accountability, and efficient team operations
Contribute to portfolio planning and cross-program prioritization discussions where appropriate
Help apply and improve R&D project management tools, templates, dashboards, and best practices
Drive scalable adoption of AI-enabled and digital program management practices, including automation, dashboards, AI-assisted synthesis, standardized workflows, and data-driven reporting, to improve planning, meeting effectiveness, action tracking, knowledge management, risk identification, portfolio governance, and cross-functional execution while ensuring human oversight, data integrity, and compliance.
Required Qualifications
Bachelor’s degree in life sciences, biomedical sciences, chemistry, engineering, or related field
8+ years of relevant experience in biotech, biopharma, or related life sciences industry
5+ years of project or program management experience supporting drug discovery and/or development programs
Demonstrated experience managing biologics programs in oncology or closely related therapeutic areas
Strong understanding of drug development from discovery through IND, including:
discovery research and candidate selection
IND-enabling toxicology and pharmacology
CMC and analytical development for biologics
regulatory documentation and IND submission processes
Proven ability to lead highly matrixed, cross-functional teams without direct authority
Excellent communication, facilitation, organizational, and stakeholder management skills
Strong problem-solving abilities with demonstrated experience managing complex timelines, dependencies, and risks
Experience preparing executive-level presentations, status reports, and governance materials
Preferred Qualifications
Advanced degree (MS, PhD, PharmD, or MBA) in a relevant scientific or business discipline
Experience with monoclonal antibodies, bispecifics, ADCs, or other complex biologic modalities in oncology
Mandarin-English Bilingual Ability
PMP or related project management certification is a plus and biotherapeutics life cycles
Experience in a fast-paced, innovation-driven biotech environment
Core Competencies
Strategic thinking with strong operational execution
Cross-functional leadership and influence
Decision facilitation and issue resolution
Planning discipline and attention to detail
Agility in a dynamic R&D environment
Strong sense of ownership and accountability
Success in this role will be defined by the ability to:
keep complex oncology biologics programs aligned and moving forward from discovery to IND
create clarity across scientific and development teams around priorities, timelines, and decisions
anticipate risks and dependencies before they become delays
enable efficient governance and high-quality decision-making
build trust across functions as a strategic and operational partner
Position Type/Expected Hours of Work
May need to work outside of standard working hours at times
This role is currently working onsite and is expected to work onsite for working hours, with flexibility to work start time. The work location for this role is in Bothell, WA.
Compensation and Benefits: The expected base salary range for this position is $100,000 - $160,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills. While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.
SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.